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Xiaofen Huang

2023-01-07

Xiaofen Huang

2021-2022, Postdoc., Tsinghua Shenzhen International Graduate School

2014-2021, Ph.D., Xiamen University, Biologicals

2010-2014, B.E., Shenyang Pharmaceutical University, Bioengineering (Pharmacy)

Huang is joined the Liu lab in Fall 2021 as a postdoctoral fellow. She received her engineering in biotechnology degree in Shenyang Pharmaceutical University, China, and holds a Ph.D. (2021) in biologics from Xiamen University, China. His doctoral work focused on developing novel and potent vaccine adjuvants and elucidating their molecular mechanisms. In the Liu lab, Huang is interested in leveraging the tonsil organoid system to study the molecular signatures of vaccine adjuvants by multiple-omics techniques. Elucidating the molecular mechanisms of protective immune pathways associated with vaccine adjuvant and identify biomarkers of effective vaccine adjuvant responses, which would support the rational design of new vaccine adjuvant for human use.   

代表作

1. Yangtao Wu1, X. Huang1, L. Yuan1, S. Wang1, Y. Zhang1, H. Xiong1, R. Chen, J. Ma, R. Qi, M. Nie, J. Xu, Z. Zhang, L. Chen, M. Wei, M. Zhou, M. Cai, Y. Shi, L. Zhang, H. Yu, J. Hong, Z. Wang, Y. Hong, M. Yue, Z. Li, D. Chen, Q. Zheng, S. Li, Y. Chen, T. Cheng, J. Zhang, T. Zhang, H. Zhu, Q. Zhao, Q. Yuan, Y. Guan, N. Xia, A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters. Sci Transl Med. 2021 Aug 11;13(606):eabg1143. https://doi: 10.1126/scitranslmed.abg1143.  

2. X. Huang, X. Wang, J. Zhang, N. Xia, Q. Zhao, Escherichia coli-derived virus-like particles in vaccine development, Npj Vaccines. 2 (2017). https://doi.org/10.1038/s41541-017-0006-8.

3. X. Huang1, Y. Li1, M. Nie, M. Yue, Y. Li, Z. Lin, H. Pan, M. Fang, T. Wu, S. Li, J. Zhang, N. Xia, Q. Zhao, Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal, J. Pharm. Anal. (2020). https://doi.org/10.1016/j.jpha.2020.08.007.

4. S. Chen1, X. Huang1, Y. Li, X. Wang, H. Pan, Z. Lin, Q. Zheng, S. Li, J. Zhang, N. Xia, Q. Zhao, Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal, Eur. J. Pharm. Biopharm. 141 (2019) 221–231. https://doi.org/10.1016/j.ejpb.2019.05.027.

5. C. Zhang1, X. Huang1, S. Chen, Y. Li, Y. Li, X. Wang, J. Tang, L. Xia, Z. Lin, W. Luo, T. Li, S. Li, J. Zhang, N. Xia, Q. Zhao, Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid, Vaccine. 36 (2018) 6761–6771. https://doi.org/10.1016/j.vaccine.2018.09.035.

6. Y. Li, X. Huang, Z. Zhang, S. Li, J. Zhang, N. Xia, Q. Zhao, Prophylactic hepatitis E vaccines: Antigenic analysis and serological evaluation, Viruses. 12 (2020). https://doi.org/10.3390/v12010109.

7. Y. Lin, X. Wang, X. Huang, J. Zhang, N. Xia, Q. Zhao, Calcium phosphate nanoparticles as a new generation vaccine adjuvant, Expert Rev. Vaccines. 16 (2017) 895–906. https://doi.org/10.1080/14760584.2017.1355733.

8. Wang X, Yin X, Zhang B, Liu C, Lin Y, Huang X, Li Y, Shen C, Zheng W, Fu G, Chen J, Wen Y, Zhang W, Pan BS, Fang M, Zheng Z, Zhang Z, Yuan Q, Fu G, Li S, Zhang J, Chen Y, Xia N, Zhao Q. A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerg Microbes Infect. 2022 Dec;11(1):914-925. https://doi.org/10.1080/22221751.2022.2050951.  

9. L. Xia, Y. Xian, D. Wang, Y. Chen, X. Huang, X. Bi, H. Yu, Z. Fu, X. Liu, S. Li, Z. An, W. Luo, Q. Zhao, N. Xia, A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5, Sci. Rep. 6 (2016).

https://doi.org/10.1038/srep19042.

10. T.Y. Zhang, X.R. Guo, Y.T. Wu, X.Z. Kang, Q.B. Zheng, R.Y. Qi, B.B. Chen, Y. Lan, M. Wei, S.J. Wang, H.L. Xiong, J.L. Cao, B.H. Zhang, X.Y. Qiao, X.F. Huang, Y. Bin Wang, M.J. Fang, Y.L. Zhang, T. Cheng, Y.X. Chen, Q.J. Zhao, S.W. Li, S.X. Ge, P.J. Chen, J. Zhang, Q. Yuan, N.S. Xia, A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice, Gut. 69 (2020) 343–354. https://doi.org/10.1136/gutjnl-2018-317725.

11. Z. Zhang, T. Zhang, L. Cao, X. Wang, J. Cao, X. Huang, Y. Cai, Z. Lin, H. Pan, Q. Yuan, M. Fang, S. Li, J. Zhang, N. Xia, Q. Zhao, Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis, Nanomedicine. 14 (2019) 2535–2548. https://doi.org/10.2217/nnm-2019-0016.

12. T. Li1, Q. Zheng1, H. Yu1, D. Wu1, W. Xue1, H. Xiong1, X. Huang, M. Nie, M. Yue, R. Rong, S. Zhang, Y. Zhang, Y. Wu, S. Wang, Z. Zha, T. Chen, T. Deng, Y. Wang, T. Zhang, Y. Chen, Q. Yuan, Q. Zhao, J. Zhang, Y. Gu, S. Li, N. Xia, SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates, Emerg. Microbes Infect. 9 (2020) 2076–2090. https://doi.org/10.1080/22221751.2020.1821583.